There exist GCs that assume that every bit pattern that is the address of something the GC is managing is in fact a pointer (and so don't release the something). This can actually work pretty well, because calls pointers are usually bigger than small common integers, and usually have to be aligned. But yes, this can cause collection of some objects to be delayed. The Boehm collector for C works this way, because it's library-based and so don't get any specific help from the compiler.
There are also GCs that are more tightly coupled to the language they're used in, and actually know the structure of the objects in memory. I've never read up specifically in stack frame handling, but you could record information to help the GC if the compiler and GC are designed to work together. One trick would be putting all the pointer references together and using one word per stack frame to record how many there are, which is not such a huge overhead. If you can work out what function corresponds to each stack frame without adding a word saying so, then you could have a per-function "stack frame layout map" compiled in. Another option would be to use tagged words, where you set the low order bit of words that are not pointers to 1, which (due to address alignment) is never needed for pointers, so you can tell them apart. That means you have to shift unboxed values in order to use them though.
